Volume 2, Issue 1, No.4 PDF DOWNLOAD
  • Title:
  • Lycopene: food resources, residences, and fitness
  • Author:

    Rehan Haider

  • Author Affiliation:

    Department of Pharmacy, University of Karachi, Karachi, Pakistan

  • Received:Aug.3, 2023
  • Accepted:Aug.30, 2023
  • Published:Sep.21, 2023
Abstract
Lycopene is a prominent crimson pigment observed abundantly in various culminations and veggies, with tomatoes and watermelons being the primary dietary sources. This carotenoid compound has garnered considerable attention because of its potential fitness benefits and antioxidant properties. Lycopene's molecular structure imparts its vibrant purple color and contributes to its potential to quench harmful reactive oxygen species. Consumption of lycopene-rich ingredients has been associated with numerous health advantages. proposed that an eating regimen rich in lycopene might also play a role in reducing the threat of continual diseases, along with cardiovascular disorders, certain cancers, and age-associated macular degeneration. Lycopene's antioxidant hobby is thought to underlie these defensive outcomes using neutralizing free radicals and mitigating oxidative pressure-induced damage. Moreover, an increasing number of studies indicate that lycopene could show anti-inflammatory and antiproliferative effects, in addition to contributing to its health benefits. Antiproliferative. Lycopene's bioavailability is motivated by way of different factors, including meal matrices, processing techniques, and personal versions. For instance, cooking and processing tomatoes can increase lycopene availability by breaking down mobile partitions and increasing their availability for absorption. In addition, the presence of nutritional fats enhances lycopene absorption, reinforcing the concept of consuming lycopene-rich foods with healthy fats to optimize its utilization. Incorporating lycopene into a balanced weight loss plan has gained attention in the realm of preventive nutrients. However, although lycopene supplementation has been investigated, nutritional assets remain in the favored direction because of the capability of interactions between isolated compounds and the synergistic consequences of entire meals. As ongoing studies delve into Lycopene's multifaceted roles and mechanisms of action, greater comprehensive expertise of its potential in promoting health and proper well-being continues to conform. 
Keywords

Lycopene, antioxidants, oxidative strain, most cancers, diabetes, cardiovascular diseases, pores, and skin disorders.

References

[1] Block G Patterson B and Subar A quit result, vegetables, and maximum cancers prevention: a top-degree view epidemiological evidence, Nutr most cancers, 18(1): 1–29, 1992.

[2] Heber, D., greens, quit result, and phytoestrogen in disorder prevention, J Postgrad Med, 50(2): 100 45–9, 2004.

[3] Olson, J.A. and Krinsky, N.I., advent: the colorful, fascinating worldwide of carotenoids: crucial physiological modulators, FASEB J, nine(15): 1547–50, 1995.

[4] Britton, G., form, and homes of carotenoids approximately function, FASEB J, 9(15): 1551–8, 1995.

[5] Nguyen ML and Schwartz, S J Lycopene: chemical and natural homes, food Technol., 53(2): 38–45, 1999.

[6] Johnson, E.J., Human studies on bioavailability and plasma reaction of lycopene, Proc Soc Exp Biol Honey, 218(2): 115-20, 1998.

[7] Forman, M.R., Lanza, E., Yong, L.C., Holden, J.M., Graubard, B.I., Beecher, G.R., Meltiz, M., Brown, E. D. and Smith, J.C., Correlation amongst nutritional assessments of carotenoid consumption and plasma carotenoid concentrations: software of the food carotenoid composition database, Am J Clin Nutr, 58 (4): 519–24, 1993.

[8] Scott, k.J., Thurnham, D.I., Hart, D.J., Bingham, S.A., and Day, okay., Correlation among Lutein, lycopene, and beta-carotene intake from greens and fruit and blood plasma concentrations in a set of ladies aged 50–65 years inside the UK, Br J Nutr, 75(3): 409–18, 1996.

[9] Nguyen, M.L. and Schwartz, S.J., The balance of lycopene in the course of food processing, Proc Soc Exp Biol Med, 218(2): 115, 1998.

[10] Clinton, S. Desirable sufficient., Lycopene: Chemistry, biology, and implications for human health and illness, Nutr. Rev, 56(2 Pt. 1): 35–51, 1998.

[11] Bramley, P.M., The law of carotenoid formation in some unspecified time in the future of tomato fruit ripening and improvement, J Exp Bot, fifty 3(377): 2107–2113, 2002.

[12] Nguyen, M., and Schwartz, S., Lycopene, in Herbal Food Colorants: Technological Advances and Generation, G. Lauro and F. Francis, Eds., Marcel Dekker: New York, 2000, pp. 153–192.

[13] Mangels, A.R., Holden, J.M., Beecher, G.R., Forman, M.R., and Lanza, E., Carotenoid content material fabric result and vegetables: evaluation of analytical statistics, J Am weight-reduction plan Assoc, 93(3): 284–96, 1993.

[14] Nebeling, L.C., Forman, M.R., Graubard, B.I., and Snyder, R.A., Modifications in carotenoid consumption inside the United States: The 1987 and 1992 countrywide health Interview Surveys, J Am healthy eating plan Assoc, 97(9): 991–6, 1997.

[15] Zhou, J.R., Gugger, E.T., and Erdman, J.W., Jr., Crystalline shape of carotenes and food matrix in carrot root lessen the relative bioavailability of beta- and alpha-carotene in a ferret model, J Am Coll Nutr, 15(1): 85–91, 1996.

[16] Roodenburg, A.J., Leenen, R., van het Hof, ok.H., Weststrate, J.A., and Tijburg, L.B., the amount of fat within the food regimen influences the bioavailability of lutein esters, but now not of alpha-carotene, beta-carotene, and the diet E in humans, Am J Clin Nutr, 71(5):1187-93, 2000

[17] Floreani, A., Baragiotta, A., Martines, D., Naccarato, R. and D'Odorico, A., Plasma stages of antioxidants in persistent cholestatic liver illness, Aliment Pharmacol Ther, 14(3): 353–8, 2000.

[18] Parker, R.S., Absorption, metabolism, and shipping of carotenoids, FASEB J, 10(5): 542–51, 1996.

[19] Goulinet, S. and Chapman, M.J., Plasma LDL, and HDL subspecies are heterogeneous in particle content cloth material of tocopherols and oxygenated and hydrocarbon carotenoids. significance for oxidation resistance Arterioscler Thromb Vasc Biol, 17(4):786–96, 1997.

[20] Sies, H. and Stahl, W., Lycopene: antioxidant and biological results and its bioavailability in human, Proc Soc Exp Biol Med,218(2): 121-4, 1998.

[21] Brown, M.J., Ferruzzi, M.G., Nguyen, M.L., Cooper, D.A., Eldridge, A.L., Schwartz, S.J., and White, W.S., carotenoid bioavailability is higher from salads ate up with full-fats than from reduced-fat salads salad dressings as measured thru manner of electrochemical detection, Am J Clin Nutr, 80(2): 396–403, 2004.

[22] Johnson, E. J., Qin, J., Krinsky, N. I., and Russell, R. M., Ingestion of a mixed dose of beta-carotene and lycopene in men do no longer affect beta-carotene absorption expertise improves lycopene absorption, J Nutr, 127(9): 1833–7, 1997.

[23] Gartner, C., Stahl, W. and Sies, H., Lycopene is more bioavailable from tomato paste than from easy tomatoes, Am J Clin Nutr,66(1):116–22, 1997.

[24] Unlu, N. Z., Bohn, T., Clinton, S. adequate., and Schwartz, S. J., Carotenoid absorption from lettuce and salsa in people haselevated the usage of the addition of avocado or avocado oil, J Nutr, a hundred 35[3): 431–6, 2005.

[25] Boileau, A.C., Merchen, N.R., Wasson, K., Atkinson, C.A., and Erdman, J.W., Jr., Cis-lycopene is greater bioavailable than trans-lycopene in vitro and in vivo in lymphatic cannulated ferrets, J Nutr, 129(6): 1176–81, 1999.

[26] Erdman, J.W., Jr., How does dietary and hormonal reputation modify bioavailability, uptake, and distribution of various isomers of lycopene? J Nutr, 135(eight): 2046S–7S, 2005.

[27] Tang, G., Ferreira, A.L., Grusak, M.A., Qin, J., Dolnikowski, G.G., Russell, R.M., and Krinsky, N.I., Bioavailability of artificial and biosynthetic deuterated lycopene in humans, J Nutr Biochem, 16(4): 229–35, 2005

[28] Shi, J. and Le Maguer, M., Lycopene in tomato: chemical and physical properties encouraged by using food processing, Crit Rev Food Sci Nutr, 40(1): 1–42, 2000.

[29] Stahl, W. and Sies, H., Consumption of lycopene and its geometric isomers are greater from warmth-handled than from uncooked tomato juice in humans, J Nutr, 122(11):2161–6, 1992.

[30] Dewanto, V., Wu, X., Adom, k.k. and Liu, R.H., warmness processing enhances dietary value tomatoes using growing total antioxidant interest, J Agric Food Chem, 50(10): 3010–4, 2002.

[31] Reboul, E., Borel, P., Mikail, C., Abou, L., Charbonnier, M., Caris-Veyrat, C., Goupy, P., Portugal, H., Lairon, D. and Amiot, M.J. Enrichment of tomato paste with 6% tomato peel will increase lycopene and bioavailability of beta-carotene in men, J Nutr, 135(four):790–4 2005.

[32] Weststrate, J.A., and van het Hof, ok.H., Sucrose polyester and carotenoid concentrations in plasma v wholesome subjects, Am J Clin Nutr, 62(3):591–7, 1995.

[33] Broekmans, W.M., Klopping-Ketelaars, I.A., Weststrate, J.A., Tijburg, L.B., van Poppel, G., Vink, A.A., Berendschot, T.T., Bots, M.L., Castenmiller, W.A. and Kardinaal, A.F., reduced carotenoid concentrations due to dietary sucrose polyesters do now not affect possible disease chance markers within the human beings, J Nutr, 133(3):720–6, 2003.

[34] Rock, C.L. and Swendseid, M.E., Plasma beta-carotene response in people after a supplemented meal with dietary pectin, Am J Clin Nutr, 55(1):96–9, 1992.

[35] Riedl, J., Linseisen, J., Hoffmann, J., and Wolfram, G., certain dietary fibers reduce the absorption of carotenoids in girls, J Nutr, 129(12):2170–6, 1999.

[36] Cardinault, N., Tyssandier, V., Grolier, P., Winklhofer-Roob, B.M., Ribalta, J., Bouteloup-Demange, C., Rock, E. and Borel, P., assessment of postprandial chylomicron carotenoid responses in younger and aged subjects, Eur J Nutr, 42(6): 315–23, 2003.

[37] Schwartz S.J. How can the metabolomic reaction to lycopene (publicity, length, intracellular attention) in human beings be effectively evaluated? J Nutr, 135(eight): 2040S–1S, 2005.

[38] Ferreira, A.L., Yeum, k.J., Liu, C., Smith, D., Krinsky, N.I., Wang, X.D., and Russell, R.M., Tissue distribution of lycopene in ferrets and rats following lycopene supplementation, J Nutr, one hundred thirty(five): 1256–60, 2000.

[39] Clinton, S.., Emenhiser, C., Schwartz, S.J., Bostwick, D.G., Williams, A.W., Moore, B.J., and Erdman, J., Jr., Cis-trans lycopene isomers, carotenoids, and retinol in the human prostate, cancer Epidemiol Biomarkers Prev, 5(10):823–33, 1996.

[40] Breemen, R.B., Xu, X., Viana, M.A., Chen, L., Stacewicz-Sapuntzakis, M., Duncan, C., Bowen, P.E. and Sharifi, R., Liquid chromatography-mass spectrometry of cis- and all-trans-lycopene in human serum and prostate tissue after nutritional supplementation with tomato sauce, J Agric meals Chem, 50(8): 2214–9, 2002.

[41] Intruder, C.M., Smith, AM, Clinton, S.k. and Schwartz, S.J., Tomato intake will increase lycopene isomer concentrations in breast milk and plasma of lactating girls, J Am weight-reduction plan Assoc, 102(nine): 1257–62, 2002.

[42] Khachik, F., Spangler, C.J., Smith, J.C., Jr., Canfield, L.M., Steck, A., and Pfander, H., identity, quantification and relative concentration of carotenoids and their metabolites in breast milk and serum, Anal Chem, 69(10): 1873-81, 1997.

[43] Ferreira, A.L., Yeum, ok.J., Russell, R.M., Krinsky, N.I., and Tang, G., Enzymatic and oxidative lycopene metabolites, J NutrBiochem, 14(9): 531–40, 2003.

[44] Khachik, F., Beecher, G.R., Smith, J.C., Jr., Lutein, lycopene and their oxidative metabolites in chemoprevention of cancer, J Cellular Biochem Suppl. 22: 236-46, 1995.

[45] Halliwell, B. and Gutteridge, J.M.C., Free Radicals in Biology and Medication, third ed., Oxford Science Guides, Oxford NY: Clarendon Press; Oxford University Press, 1999, xxxi, 936.

[46] Di Mascio, P., Kaiser, S., and Sies, H., Lycopene as the best biological carotenoid singlet oxygen quencher, Arch Biochem Biophys, 274(2): 532–8, 1989.

[47] Di Mascio, P., Devasagayam, T.P., Kaiser, S., and Sies, H., Carotenoids, tocopherols, and thiols as biological singlet molecular oxygen quenchers, Biochem Soc Trans, 18(6): 1054–6, 1990.

[48] Gerster, H., Capability roles of lycopene in human fitness, J Am Coll Nutr, 16(2): 109–26, 1997.

[49] Gerster, H., Anticarcinogenic impact of not unusual carotenoids, Int J Vitam Nutr Res, 63(2): 93–121, 1993.

[50] Handelman, G.J., Packer, L., and Move, C.E., Destruction of tocopherols, carotenoids, and retinol in human plasma via cigarette smoke, Am J Clin Nutr, 63(4): 559–65, 1996.

[51] Gupta, S., Trivedi, D., Srivastava, S., Joshi, S., Halder, N., and Verma, S.D., Lycopene attenuates experimental cataract development induced by way of oxidative strain: in vitro and in vivo studies, vitamins, 19(9): 794–nine, 2003.

[52] Beckman, J.S., Beckman, T.W., Chen, J., Marshall, P.A., and Freeman, B.A., obvious hydroxyl radical generation through peroxynitrite: implications for endothelial harm by using nitric oxide and superoxide, Proc Natl Acad Sci USA, 87(4): 1620–4, 1990.

[53] Panasenko, O.M., Sharov, V.S., Briviba, ok. and Sies, H., the interplay of peroxynitrite with carotenoids in human low-density lipoproteins, Arch Biochem Biophys, 373(1): 302–5, 2000.

[54] Hadley, C.W., Clinton, S.., and Schwartz, S.J., Consumption of processed tomato merchandise will increase plasma concentrations of lycopene in association with decreased sensitivity to lipoproteins oxidative harm, J Nutr, 133(3): 727–32, 2003.

[55] Rao, A.V., Processed tomato products as a source of nutritional lycopene: bioavailability and antioxidant residences, Can J food plan Pract Res, 65(4): 161–5, 2004.

[56] Agarwal, S. and Rao, A.V., Tomato lycopene and coffee-density lipoprotein oxidation: a human dietary intervention look at, Lipids, 33(10): 981–4, 1998.

[57] Ford, E.S., Liu, S., Mannino, D.M., Giles, W.H., and Smith, S.J. C-reactive protein concentrations and blood vitamin, carotenoid, and selenium concentrations in US adults, Eur J Clin Nutr, 57(9): 1157–63, 2003.

[58] Bohm, F., aspect, R., Burke, M. and Truscott, T.G., dietary consumption of lycopene guard human cells of singlet oxygen and nitrogen dioxide-ROS additives of cigarette smoke, J Photochem Photobiol B, 64(2–3): 176–8, 2001.

[59] Mayne, S. T., Cartmel, B., Lin, H., Zheng, T., and Goodwin, W. J., Jr., Low plasma lycopene awareness is associated with multiplied mortality in a cohort of patients with preceding oral pharynx or larynx of most cancers, J Am Coll Nutr, 23(1): 34–42, 2004.

[60] Giovannucci, E., Tomatoes, tomato-primarily based merchandise, lycopene, and most cancers: a review of epidemiological literature, J Natl Cancer Inst, 91(4):317–31, 1999.

[61] Giovannucci, E., Rimm, E.B., Liu, Y., Stampfer, M.J., and Willett, W.C., A potential examine of tomato merchandise, lycopene, and prostate most cancers chance, J Natl Cancer Inst, 94(5): 391–8, 2002.

[62] Giovannucci, E., Ascherio, A., Rimm, E.B., Stampfer, M.J., Colditz, G.A., and Willett, W.C., profits carotenoids and retinol in relation to prostate cancer danger, J Natl cancer Inst, 87(23): 1767–76, 1995.

[63] Mills, P.k., Beeson, W.L., Phillips, R.L. and Fraser, G.E., The eating regimen, way of life and Prostate Cohort observe most cancers in Adventist guys, most cancers, 64(3): 598–604, 1989.

[64] Giovannucci, E., Tomato merchandise, lycopene, and prostate cancer: epidemiological evaluation literature, J Nutr, 130 five(8): 2030S–1S, 2005.

[65] Michaud, D.S., Feskanich, D., Rimm, E.B., Colditz, G.A., Speizer, F.E., Willett, W.C. and Giovan Nucci, E., consumption of unique carotenoids and the chance of lung maximum cancers in 2 US potential cohorts, I J Clin Nutr, 70 (4):990–7, 2000.

[66] Levi, F., Pasche, C., Lucchini, F. and l. a. Vecchia, C., nutritional consumption of decided on micronutrients and breast cancer risk, Int J maximum cancers, 91(2):260–3, 2001.

[67] Nkondjock, A., Ghadirian, P., Johnson, K. C. and Krewski, D., Nutritional consumption of lycopene is associated with reduced threat of pancreatic most cancers, J Nutr, one hundred thirty 5(3): 592–7, 2005.

[68] Levy, J., Bosin, E., Feldman, B., Giat, Y., Minister, A., Danilenko, M., and Sharoni, Y., Lycopene is a more potent inhibitor of human maximum cancers cellular proliferation than alpha-carotene or beta-carotene, Nutr cancer, 24(3): 257–66, 1995.

[69] Kim, L., Rao, AV, and Rao, L.G., Impact of lycopene on Ln Cap prostate most cancers cells in lifestyle, J Med meals, 5(4): 181–7, 2002.

[70] Ben-Dor, A., Steiner, M., Gheber, L., Danilenko, M., Dubi, N., Linnewiel, good enough., Zick, A., Sharoni, Y., and Levy, J., Carotenoids prompt the antioxidant reaction detail transcriptional device, Mol maximum cancers Ther, 4(1): 177–86, 2005.

[71] Karas, M., Amir, H., Fishman, D., Danilenko, M., Segal, S., Nahum, A., Kaufmann, A., Giat, Y., Levy, J. and Sharoni, Y., Lycopene interferes with cellular cycle development and insulin-like boom aspect I signaling in breast most cancers cells, Nutr most cancers, 36(1): 101–11, 2000.

[72] Amir, H., Karas, M., Giat, J., Danilenko, M., Levy, R., Yermiahu, T., Levy, J., and Sharoni, Y., Lycopene and 1,25-dihydroxy vitamins D3 artwork together to inhibit mobile cycle development and its induction differentiation in HL-60 leukemia cells, Nutr most cancers, 33(1): 10 5–12, 1999

[73] Obermuller-Jevic, U.C., Olano-Martin, E., Corbacho, A.M., Eiserich, J.P., van der Vliet, A., Valacchi, G., bypass, C.E., and Packer, L., Lycopene inhibits the increase of regular human prostate epithelial cells in vitro, J Nutr, 133(11): 3356–60, 2003.

[74] Matos, H.R., Capelozzi, V.L., Gomes, O.F., Mascio, P.D., and Medeiros, M.H., Lycopene inhibits DNA harm and liver necrosis in rats dealt with with ferric nitrilotriacetate, Arch Biochem Biophys, 396(2): 171–7, 2001.

[75] Bhuvaneswari, V., Velmurugan, B., and Nagini, S., Induction of glutathione-based hepatic lycopene bio transformation enzymes in a hamster cheek pouch version of carcinogenesis, J Biochem Mol Biol Biophys, 6(4): 257-60, 2002.

[76] Kim, D.J., Takasuka, N., Kim, J.M., Sekine, ok., Ota, T., Asamoto, M., Murakoshi, M., Nishino, H., Nir, Z. and Tsuda, H., Chemoprevention through lycopene in murine lung neoplasia after mixed initiation of treatment with DEN, MNU and DMH, maximum cancers Lett, 100 and 20(1): 15–22, 1997.

[77] Liu, C., Lian, F., Smith, D.E., Russell, R.M., and Wang, X.D., Lycopene supplementation inhibits pulmonary squamous metaplasia and induces apoptosis through up-regulation of insulin-like growth detail binding protein three in ferrets uncovered to cigarette smoke, maximum cancers Res, 63(12): 3138–40 4, 2003.

[78] Boileau, T.W., Liao, Z., Kim, S., Lemeshow, S., Erdman, J.W., Jr., and Clinton, S.K., Prostate carcinogenesis in N-methyl-Nnitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or an energy-restricted diet, J Natl Cancer Inst, 95(21): 1578–86, 2003.

[79] Herzog, A., Siler, U., Spitzer, V., Seifert, N., Denelavas, A., Hunziker, P.B., Hunziker, W., Goralczyk, R. and Wertz, yes., Lycopene diminished deoxyribonucleic acid verbalization of steroid dreams and angering tombstones in common informer prostate, FASEB J, 19(2): 272–4, 2005.

[80] Nagasawa, H., Mitamura, T., Sakamoto, S. and Yamamoto, ok., results of lycopene on impulsive mammary swelling happening in SHN virgin rodent, Anticancer Res, 15(4): 1173–eight, 1995.

[81] Clinton S.k., Tomatoes, or Lyc: a duty in prostate carcinogenesis? J Nutr, 130 5(8: 2057S–9S, 2005.

[82] Bowen, P., Chen, L., Stacewicz-Sapuntzakis, M., Duncan, C., Sharifi, R., Ghosh, L., Kim, H.S., Christov-Tzelkov, K. and truck Breemen, R., Tomato condiment supplementation and prostate maximum cancers: lycopene build-up and timbre of carcinogenesis biomarkers, Exp Biol Med (can likewise forest), 227(10): 886–93, 2002.

[83] Kucuk, O.; Sarkar, F.H.; Sakr, W.; Djuric, Z.; Pollak, M.N.; Khachik, F.; Li, Y.W.; Banerjee, M.; Grignon, D.; Bertram, J. S.; Crissman, J. D.; Pontes, E. J.; inflexible, D. P. Jr. point II randomized experimental trial of lycopene supplementation before radical prostatectomy. most cancers Epidemiol Biomarkers prior, 10(8):861–eight, 2001.

[84] Hulten, enough., Van Kappel, A.L., Winkvist, A., Kaaks, R., Hallmans, G., Lenner, P., and Riboli, E., Carotenoids, beginningtocopherols, and retinol in skin and feelings maximum cancers danger in northerly Sweden, tumor causes control, 12(6): 529–37, 2001.

[85] Muhlhofer, A., Buhler-Ritter, B., Frank, J., Zoller, W.G., Merkle, P., Bosse, A., Heinrich, F., and Biesalski, H.k., Carotenoids are curbed in biopsies from colorectal adenomas, Clin Nutr, 22(1): 65–70, 2003.

[86] Helzlsouer, K. J., Comstock, G.W., and Morris, J.S., Selenium, lycopene, beginning-tocopherol, being tested-carotene, retinol, and next pouch malignancy, malignancy Res, quadragenarian nine(21): 6144–8, 1989.

[87] Ribaya-Mercado, J.D., Garmyn, M., Gilchrest, B.A. and Russell, R.M., pores, and skin lycopene has ruined a suggestion of choice over testing-carotene inside the route of ultraviolet education cruel beings, J Nutr, individual hundred twenty 5(7): 1854–nine, 1995.

[88] Kochanek, okay.D., Murphy, S.L., Anderson, R.N., and Scott, C., Deaths: very last records for 2002, Natl essential Stat Rep, having 50 of something 3(5): 1–a hundred and 15, 2004.

[89] Rao, AV, Lycopene, tomatoes and the stop of heart failure coronary congestive heart failure, Exp Biol Med (can furthermore inflexible), 227(10): 908–13, 2002.

[90] Dugas, T.R., Morel, D.W., and Harrison, E.H., digestive supplementation accompanying testing-carotene but not any more accompanying lycopene, prevents endothelial container-interceded burning of reduced-bulk lipoprotein, lax radicals Biol Med, 26(9-10): 1238-44, 1999.

[91] Kohlmeier, L., Kark, J.D., Gomez-Gracia, E., Martin, B.C., Steck, S.E., Kardinaal, A.F., Ringstad, J., Thamm, M., Masaev, V., Riemersma, R., Martin-Moreno, J.M., Huttunen, J.okay. and Kok, F.J., Lycopene and hazard of heart attack inside the EURAMIC trial, Am J Epidemiol, 146(8): 618–26, 1997.

[92] Craft, N. E., Haitema, T. B., Garnett, okay. M., Fitch, OK. A. and Dorey, C. okay., Carotenoid, tocopherol and retinol concentrations inside the mind of the old, J Nutr fitness expanding vintage, 8(three): 156–60, 2004.

[93] Rao, A.V., Fleshner, N., and Agarwal, S., Serum and fabric lycopene and biomarkers of corrosion in inmates accompanying prostate most cancers: a case-maneuver scrutinize at, Nutr malignancy, 33(2): 159– 64, 1999.

[94] Freeman, V.L., Meydani, M., Yong, S., Pyle, J., Wan, Y., Arvizu-Durazo, R., and Liao, Y., Prostatic levels of tocopherols, carotenoids, and retinol about red body fluid levels and their typical able to be consumed consumption, Am J Epidemiol, 151(2):109–18, 2000.

[95] Kaplan, L.A., Lau, J.M., and Stein, E.A., Carotenoid arrangement, concentrations and friendships in miscellaneous human means, Clin Physiol Biochem, 8(1): 1–10, 1990.

[96] Schmitz, H.H., Poor, C.L., Wellman, R.B., and Erdman, J.W., Jr., Concentrations of picked carotenoids and source of nourishment A cruel liver, kind, and body part fabric, J Nutr, 121(10): 1613–21, 1991.

[97] Nierenberg, D.W. and Nann, S.L., A form for deciding concentrations of retinol, tocopherol, and five carotenoids cruel body tissue and fabric samples, Am J Clin Nutr, 56(2): 417–26, 1992.

[98] Stahl, W., Schwarz, W., Sundquist, A.R. and Sies, H., Cis-trans isomers of lycopene and testing-carotene cruel antitoxin and tissues, Arch Biochem Biophys, 294(1):173–7, 1992.

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