Objective: To discuss the effect of pharmaceutical intervention on improving the rationality of the use of antibiotics. Methods: A total of 168 patients treated with antibiotics in this hospital from January 2019 to March 2020 were selected, and were divided into the control group (80) and the observation group (88) based on their acceptance of pharmaceutical intervention during medication. The control group received no pharmaceutical intervention, and the observation group received pharmaceutical intervention, and the use of antibiotics was compared between the two group. Results: The usage rate of an antimicrobial, the usage rate of two antibiotics and the total usage rate in the observation group were lower than those in the control group, showing statistical differences (P < 0.05); there were no statistical differences in the usage rates of three or more antibiotics between the two groups (P > 0.05); the rates of irrational drug selection, too frequent change of drugs, too high dosage, failure to administer drugs according to pharmacokinetics, and irrational drug combination in the observation group were lower than those in the control group, showing statistical differences (P < 0.05); the satisfaction in the use of antibiotics in the observation group was higher than that in the control group, showing statistical differences (P < 0.05). Conclusion: Pharmaceutical intervention can effectively reduce the usage rate of antibiotics in clinical treatment and improve the rationality of the use of antibiotics. 

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