Objective: To analyze the effect of pharmaceutical intervention on reducing the incidence rate of irrational drug use during the use of antibiotics in patients. Methods: A total of 840 patients treated with antibiotics in our hospital were divided into the experimental group (420) and the control group (420) by random number expression. The control group was not given pharmaceutical intervention and the experimental group was given pharmaceutical intervention during drug use, and the irrational use of antibiotics, combination of antibiotics, drug expense and drug course were compared between the two groups. The incidence rate of irrational use of antibiotics, combination of antibiotics, drug expense and drug course were compared between the two groups. Results: The incidence rate of irrational use of antibiotics (5%) in the experimental group was lower than that (25.95%) in the control group, the proportion of combination of antibiotics (95.48%) was higher than that (79.19%) in the control group, the drug expense [(115.36±11.25) yuan] was lower than that [(264.35±21.31) yuan] in the control group, and the duration of antibiotics [(3.24±0.54) days] was shorter than that [(5.24±0.68) days] in the control group (P < 0.05 for all). Conclusion: Pharmaceutical intervention could reduce the incidence rate of irrational use of antibiotics and the drug expense and shorten the course of antibiotics during the use of antibiotics in patients. 

[1] HU Ming-zhu. Rational use of antimicrobial drugs pharmaceutical intervention measures and clinical value[J]. China Continuing Medical Education, 2019, 11(20):143-145.

[2] XIAO Xue-xiu. Analysis on the type and effect of pharmaceutical intervention on clinical rational use of antibiotics[J]. Journal of Clinical Rational Drug Use, 2019, 12(17):109-110.

[3] SU Hui-na. Evaluation of pharmaceutical intervention and implementation value in clinical rational use of antibiotics[J]. Cardiovascular Disease Journal of Integrated Traditional Chinese and Western Medicine (Electronic), 2019, 7(02):171-174

[4] ZHANG Xiao-ming. Effect observation of pharmaceutical intervention in clinical rational sue of antibiotics[J]. Home Medicine, Medical Treatment and Drug Selection, 2018, (10):162.

[5] LIANG Zhong. Effect of evidence-based pharmaceutical intervention on promoting rational use of antibiotics[J]. Home Medicine, Medical Treatment and Drug Selection, 2018, (06):134.

[6] CHEN Hai-li. Preliminary analysis on the meaning of pharmaceutical intervention on rational use of antibiotics[J]. Journal of North Pharmacy, 2018, 15(03):166-167.