Objective: To analyze the effect of pharmaceutical intervention in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) on the rational use of antibiotics. Methods: In this study, 95 patients with AECOPD treated in our hospital from January 2019 to December 2019 were randomly selected, numbered, and divided into the control group and the observation group by odd or even number, of which the control group was given conventional medication guidance, and the observation group was given pharmaceutical intervention. The varieties of antibiotics used in patients were counted, the irrational use of antibiotics in each group was recorded, the total incidence rate was calculated, and quality scores of antibiotics use before and after intervention were evaluated. Results: Common clinical antibiotics mainly included cephalosporins, macrolides and quinolones; the incidence rate of irrational use of antibiotics in the observation group was significantly lower than that in the control group (P < 0.05). The scores of antibiotics use between the two groups showed no statistical difference before intervention (P > 0.05), and significantly increased after intervention, of which those in the observation group were significantly higher than those in the control group (P < 0.05). Conclusion: Pharmaceutical intervention given during the use of antibiotics in patients with AECOPD can effectively improve the rationality of the use of drugs and ensure the safety of drugs use of patients, and thus is worthy of promotion. 

[1] WANG Hai-yan. Analysis of irrational use of antibiotics in AECOPD[J]. Psychological Doctor, 2019, 25(5):61-62.

[2] ZHANG Li-ping, DONG Hua. Evaluation of intervention effects of standardized pharmaceutical care on clinical treatment of AECOPD patients[J]. China Pharmacy, 2017, 28(20):2847-2851.

[3] XU Xiao-yun, ZHOU Rong-wei. Analysis of rational drug use of COPD overlapped with bronchial asthma[J]. Journal of Clinical Rational Drug Use, 2018, 11(35):109-110.

[4] YUN Jun-jun, XU Jian. Evaluation of rationality of drug use in COPD patients by combination of DUI and DUE[J]. Journal of China Prescription Drug, 2017, 15(12):38-40.

[5] LIU Peng. Application of antibiotics in patients with AECOPD in a hospital[J]. Journal of China Prescription Drug, 2020, 18(3):56-58.

[6] ZHENG En-xiang. Effect analysis of quality clinical pharmaceutical care for patients treated with antibiotics[J]. Contemporary Medicine Forum, 2019, 17(23):67-68.

[7] MA Xiao-ping, YU Jiang. Effect of pharmaceutical care intervention in the application of antibiotics in Respiratory Medicine Department[J]. Journal of Clinical Rational Drug Use, 2019, 12(29):101-103,109.

[8] CHEN Qing-bin. Effect of pharmacological services and special rectification of antibacterial drugs on the safe use of antibacterial drugs in patients with ICU[J]. China Health Standard Management, 2019, 10(5):73-75. 4

[9] DAI Rou-li, BAO Chuang, LI Xin, et al. The efficacy, safety and economy of antimicrobial agents in patients with acute exacerbation of chronic obstructive pulmonary disease[J]. Modern Medical Journal, 2019, 47 (9):1063-1069.

[10] CHEN Dong-mei, ZHANG Li, LI Ming-biao, et al. Analysis of the utilization of antibacterial drugs in 100 cases of old community-acquired pneumonia with chronic obstructive pulmonary disease[J]. Chinese Journal of Primary Medicine and Pharmacy, 2019, 26 (11):1311-1315.

[11] SONG Zheng, ZHENG Cui-cui, XING Shu-li, et al. Integrated pharmaceutical care for asthma-COPD overlap syndrome patients[J]. Herald of Medicine, 2018, 37(3):319-322.

[12] HUANG Jin-huan, LI Ge-ning. Diagnostic value of detection of PCT, CRP, and WBC for acute exacerbation of chronic obstructive pulmonary disease[J]. Modern Hospital, 2020, 20(2):308-309, 312.