Progress in the Research of Skull Repair Materials

Journals

Title：
Progress in the Research of Skull Repair Materials
Author：
Jinan Wu¹, Mei-li Qi^1,2*, Kunshan Yuan², Jinping Ren², Haijun Zhang³
Author Affiliation：
1.Shandong Jiaotong University, Ji’nan, China
2.National United Engineering Laboratory for Biomedical Material Modification, Dezhou, China
3.Medical College of Tongji University, Shanghai, China
Received：Feb.17, 2023
Accepted：Mar.2, 2023
Published：Mar.20, 2023

Abstract

Skull defect is a common clinical neurosurgery disease. If not repaired in time, it will seriously threaten the safety of patients. The skull defect repair of children is more complicated because their skull is in the growth stage. To improve the treatment level of skull defect, skull repair materials used to replace skull defects have evolved in recent years. An ideal material for skull repair should meet the requirements of good osseointegration, biodegradability and conformability, and finally a perfect fusion with the surrounding bone tissue. In this article, the evolution of current materials utilized in cranioplasty are comprehensively reviewed. Firstly, the existing situation of skull repair materials used in clinical practice are first introduced, including autologous cranial materials and synthetic materials. Secondly, the research hotspots of skull repair materials are summarized, including bone-induced framework and growth factors, and points out the scientific problems that need to be solved in the current research. Finally, the future development direction and clinical application prospect of skull repair are prospected, in order to provide the thinking and reference for the treatment of skull defect.

Keywords

Skull repair, skull defect, growth factor, bone induced frame.

Doi

https://doi.org/10.58396/bephs020101

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